Polymorphism of Microsatellite Loci in the Japanese Population
Microsatellite markers are exploited widely for forensic medicine and for
genetic studies to identify genes involved in monogenic and multifactorial
diseases. Genotypic information, such as allelic frequencies and heterozygosities,
often influences statistical study, hence a highly polymorphic informative
marker set should be optimized to a given population. Marker information
is available through various databases. However most of data are obtained
from the Caucasian population. The data from the Asian population currently
available are: 358 and 406 markers in the Japanese population, 285 markers
in the Chinese Singaporeans and 811 markers in the Taiwanese population.
These studies analyzed commercially available markers which are selected
based on heterozygosities in Caucasian. The significant differences in
allelic distributions of certain markers between East Asian and Caucasian
population were found in these studies. Thus, gathering information on
additional microsatellite markers in Asian population is essential for
an efficient mapping of disease genes in Asia.
We examined 64 normal Japanese chromosomes to determine the heterozygosities
and allele frequencies for 4868 microsatellite markers which have been
described in the report of deCODE Genetics in 2002 (Kong A et al. Nat.
Ken Yamamoto MD
Division of Genome Analysis
Research Center for Genetic Information
Medical Institute of Bioregulation
文部科学省委託研究開発事業 統合データベースプロジェクト におけるアーカイブはこちら