Polymorphism of Microsatellite Loci in the Japanese Population

Microsatellite markers are exploited widely for forensic medicine and for genetic studies to identify genes involved in monogenic and multifactorial diseases. Genotypic information, such as allelic frequencies and heterozygosities, often influences statistical study, hence a highly polymorphic informative marker set should be optimized to a given population. Marker information is available through various databases. However most of data are obtained from the Caucasian population. The data from the Asian population currently available are: 358 and 406 markers in the Japanese population, 285 markers in the Chinese Singaporeans and 811 markers in the Taiwanese population. These studies analyzed commercially available markers which are selected based on heterozygosities in Caucasian. The significant differences in allelic distributions of certain markers between East Asian and Caucasian population were found in these studies. Thus, gathering information on additional microsatellite markers in Asian population is essential for an efficient mapping of disease genes in Asia.

  We examined 64 normal Japanese chromosomes to determine the heterozygosities and allele frequencies for 4868 microsatellite markers which have been described in the report of deCODE Genetics in 2002 (Kong A et al. Nat. Genet. 2002).

日本人におけるマイクロサテライトマーカーへテロ接合度の情報(4868マーカー)

chromosome 1 chromosome 9 chromosome 17 linkage set v1
chromosome 2 chromosome 10 chromosome 18
chromosome 3 chromosome 11 chromosome 19
chromosome 4 chromosome 12 chromosome 20
chromosome 5

chromosome 13

chromosome 21
chromosome 6 chromosome 14 chromosome 22
chromosome 7 chromosome 15 chromosome X
chromosome 8 chromosome 16 summary


Ken Yamamoto MD
Division of Genome Analysis
Research Center for Genetic Information
Medical Institute of Bioregulation
Kyushu University

kyama@bioreg.kyushu-u.ac.jp
TEL 81-92-642-6170

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